There, he claims that 'The Powerpuff Girls may have won this battle but they have already lost the war. They transmit large quantities of to Silico's very dark base. After the Amoeba Boys fail to place the microchip at the internet's core and are defeated by The Powerpuff Girls, the chip is left behind and small viruses emerge from it, scattering throughout the internet. He gives them a microchip that he claims will destroy the internet when placed at its core, which the Amoeba Boys have no interest in until he tells them that it will really annoy The Powerpuff Girls.

In ' Viral Spiral', after overhearing The Amoeba Boys' plotting to ruin a new internet-based game created by Bubbles, Silico approaches them with an offer for them to make a bigger impact on the internet as a whole. Distraught after losing so many of his 'friends' that night, Silico made a vow that he will destroy The Powerpuff Girls, and he can take any shape. Just as he was coming back that same night, The Powerpuff Girls were fighting the Fancy Monster and knocked him into Silico's house, destroying it along with every one of his beloved robots. One day, he left for the Circuit Barn to pick up some RAM cards for them. But he realized that he was gifted with the knowledge and talents of engineering, which he used to make his own 'friends', robots that would keep him company and make him feel loved. His parents were never around to comfort him, and he didn't have many friends to play with.

Years prior to the series, Silico was just a lonely child.

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